GeneWebEx: Gene Annotation Web Extraction, Aggregation, and Updating from Web-Based Biomolecular Databanks

Numerous genomic annotations are currently stored in different web-accessible databanks that scientists need to mine with user-defined queries and in a batch mode to orderly integrate the diverse mined data in suitable user-customizable working environments. Unfortunately, to date, most accessible databanks can be interrogated only for a single gene or protein at a time and generally the data retrieved are available in HTML page format only. We developed GeneWebEx to effectively mine data of interest in different HTML pages of web-based databanks, and organize extracted data for further analyses. GeneWebEx utilizes userdefined templates to identify data to extract, and aggregates and structures them in a database designed to allocate the various extractions from distinct biomolecular databanks. Moreover, a template-based module enables automatic updating of extracted data. Validations performed on GeneWebEx allowed us to efficiently gather relevant annotations from various sources, and comprehensively query them to highlight significant biological characteristics.